Positive benefits of a pharmacist-managed hypertension clinic in Nigeria

Public Health. 2005 Sep;119(9):792-8. doi: 10.1016/j.puhe.2004.11.009.


Objective: The aim of this study was to determine whether the provision of further practice-based support by pharmacists will bring about improved outcomes for blood pressure (BP) control in middle-aged and elderly Nigerian hypertensive patients managed with combination diuretics (amiloride hydrochloride 5 mg+hydrochlorothiazide 50 mg) and/or methyl dopa at the primary care level.

Design and setting: This was a 1-year prospective, randomized cohort study of the outpatients of a state comprehensive health centre in South-western Nigeria. Free primary health services including free drugs were provided for all patients.

Patients and method: The study population comprised 51 Nigerian patients with uncomplicated hypertension aged 45 years or more, with a 0.2-3.0-year history of hypertension, registered at the Comprehensive Health Centre, Ife between October 2002 and March 2003. They were invited into the pharmacist-managed hypertension clinic and followed for the study period. Participating pharmacists counselled for current medication, personalized goals of lifestyle modification stressing weight loss and/or increased activity, increased patient awareness by providing relevant education about hypertension and associated/related diseases, adjusted drug therapy to optimize effectiveness and minimize adverse events, utilized treatment schedules that enhanced patients' adherence to therapy, and monitored treatment outcomes between enrollment and return visits. Patient satisfaction and the number of treatment failures within 6 months post enrollment were compared with retrospective data from our earlier study involving physician-managed patients under a similar setting.

Results: Uncontrolled BP reduced from 92 to 36.2% by 10.15+/-5.02 days after enrollment. Treatment failures were observed at 5.9% of the total return visits (n=184) within 6 months.

Conclusion: Pharmacist-managed hypertension clinics can improve BP control, reduce treatment failure and increase patient satisfaction.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Amiloride / administration & dosage*
  • Antihypertensive Agents / administration & dosage*
  • Community Health Centers / organization & administration*
  • Counseling
  • Diuretics / administration & dosage*
  • Drug Monitoring
  • Drug Therapy, Combination
  • Female
  • Health Services Accessibility
  • Humans
  • Hydrochlorothiazide / administration & dosage*
  • Hypertension / diagnosis
  • Hypertension / drug therapy*
  • Male
  • Methyldopa / administration & dosage
  • Middle Aged
  • Nigeria
  • Patient Education as Topic
  • Pharmacists*
  • Program Evaluation
  • Treatment Outcome


  • Antihypertensive Agents
  • Diuretics
  • Hydrochlorothiazide
  • Methyldopa
  • Amiloride