Abstract
The purpose of this study was to synthesize a novel prodrug of ethacrynic acid (ECA) with short chain polyethylene glycols (PEGs) and codrugs of ECA with the beta-adrenergic blocking agent atenolol (ATL) or timolol (TML) to overcome the adverse effects of ECA and to enhance its physicochemical properties.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic beta-Antagonists / chemical synthesis*
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Adrenergic beta-Antagonists / pharmacology
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Atenolol / pharmacology
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Ethacrynic Acid / adverse effects
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Ethacrynic Acid / chemical synthesis*
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Ethacrynic Acid / pharmacology
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Ethacrynic Acid / therapeutic use
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Glaucoma / drug therapy*
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Polyethylene Glycols / chemistry
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Prodrugs / chemical synthesis*
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Prodrugs / pharmacology
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Prodrugs / therapeutic use
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Timolol / pharmacology
Substances
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Adrenergic beta-Antagonists
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Prodrugs
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Polyethylene Glycols
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Atenolol
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Timolol
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Ethacrynic Acid