Biotin-dependent regulation of gene expression in human cells

J Nutr Biochem. 2005 Jul;16(7):432-4. doi: 10.1016/j.jnutbio.2005.03.021.


The role of biotin as cofactor of carboxylases and its importance in metabolic homeostasis are well known. In recent years, different researchers have suggested the participation of biotin as a regulator molecule in the control of gene expression. Biotin-dependent gene expression requires of the transformation of biotin into biotinyl-5'-AMP by holocarboxylase synthetase and the activation of soluble guanylate cyclase and a cGMP-dependent protein kinase. The regulatory role of biotin is responsible for the correct expression of enzymes involved in biotin utilization in human cells. We propose that this mechanism protects the brain from biotin deficiency.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biotin / deficiency
  • Biotin / metabolism*
  • Biotinidase Deficiency / metabolism
  • Carbon-Nitrogen Ligases / genetics
  • Carbon-Nitrogen Ligases / metabolism
  • Gene Expression Regulation*
  • Holocarboxylase Synthetase Deficiency / metabolism
  • Humans
  • Symporters / genetics
  • Symporters / metabolism


  • Symporters
  • biotin transporter
  • Biotin
  • Carbon-Nitrogen Ligases
  • holocarboxylase synthetases