Protein oligomerization: how and why

Bioorg Med Chem. 2005 Sep 1;13(17):5013-20. doi: 10.1016/j.bmc.2005.05.037.


A large fraction of cellular proteins are oligomeric. Protein oligomerization may often be an advantageous feature from the perspective of protein evolution and has probably evolved by a variety of mechanisms. The study of protein oligomerization may provide insights into the early protein environment and the evolution of modern proteins. Oligomeric mini-proteins, short peptides with discrete protein-like structures, may serve as valuable models for understanding features of protein oligomerization.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Biopolymers / chemistry*
  • Protein Folding
  • Proteins / chemistry*


  • Biopolymers
  • Proteins