Synthesis of novel curcumin mimics with asymmetrical units and their anti-angiogenic activity

Bioorg Med Chem Lett. 2005 Aug 15;15(16):3782-6. doi: 10.1016/j.bmcl.2005.05.064.

Abstract

Novel curcumin mimics with asymmetrical units phenyl group with alkyl amide, chloro-substituted benzamide, or heteroaromatic amide moieties were synthesized and their anti-angiogenic activity was evaluated with the proliferation and tube formation inhibitory activity on the human umbilical vein endothelial cells. Compounds 5, 14, 17, and 18 showed potent growth inhibitory activity and tube formation inhibitory activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / chemical synthesis*
  • Angiogenesis Inhibitors / chemistry
  • Angiogenesis Inhibitors / pharmacology*
  • Cell Proliferation / drug effects
  • Curcumin / analogs & derivatives
  • Curcumin / chemical synthesis*
  • Curcumin / pharmacology*
  • Endothelial Cells / drug effects
  • Humans
  • Molecular Mimicry*
  • Molecular Structure
  • Structure-Activity Relationship

Substances

  • Angiogenesis Inhibitors
  • Curcumin