Cellular replicative capacity correlates primarily with species body mass not longevity

Mech Ageing Dev. 2005 Oct;126(10):1130-3. doi: 10.1016/j.mad.2005.05.004.


Although the limited replicative capacity of human fibroblasts in culture is frequently used as a model for aging, a question of major interest is whether the relationship between in vitro fibroblast proliferative capacity and species longevity is primary or secondary to a relationship with species body size. In this report we establish that body mass is the primary correlative of proliferative potential rather than species life-span.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Body Size
  • Body Weight / physiology*
  • Cell Line
  • Cell Proliferation*
  • Cellular Senescence / physiology*
  • Fibroblasts / physiology*
  • Humans
  • Longevity / physiology*
  • Middle Aged
  • Species Specificity