The Aphrodisiac Herb Tribulus Terrestris Does Not Influence the Androgen Production in Young Men

J Ethnopharmacol. 2005 Oct 3;101(1-3):319-23. doi: 10.1016/j.jep.2005.05.017.

Abstract

Objective: The aim of the current study is to investigate the influence of Tribulus terrestris extract on androgen metabolism in young males.

Design and methods: Twenty-one healthy young 20-36 years old men with body weight ranging from 60 to 125 kg were randomly separated into three groups-two experimental (each n=7) and a control (placebo) one (n=7). The experimental groups were named TT1 and TT2 and the subjects were assigned to consume 20 and 10 mg/kg body weight per day of Tribulus terrestris extract, respectively, separated into three daily intakes for 4 weeks. Testosterone, androstenedione and luteinizing hormone levels in the serum were measured 24 h before supplementation (clear probe), and at 24, 72, 240, 408 and 576 h from the beginning of the supplementation.

Results: There was no significant difference between Tribulus terrestris supplemented groups and controls in the serum testosterone (TT1 (mean+/-S.D.: 15.75+/-1.75 nmol/l); TT2 (mean+/-S.D.: 16.32+/-1.57 nmol/l); controls (mean+/-S.D.: 17.74+/-1.09 nmol/l) (p>0.05)), androstenedione (TT1 (mean+/-S.D.: 1.927+/-0.126 ng/ml); TT2 (mean+/-S.D.: 2.026+/-0.256 ng/ml); controls (mean+/-S.D.: 1.952+/-0.236 ng/ml) (p>0.05)) or luteinizing hormone (TT1 (mean+/-S.D.: 4.662+/-0.274U/l); TT2 (mean+/-S.D.: 4.103+/-0.869U/l); controls (mean+/-S.D.: 4.170+/-0.406U/l) (p>0.05)) levels. All results were within the normal range. The findings in the current study anticipate that Tribulus terrestris steroid saponins possess neither direct nor indirect androgen-increasing properties. The study will be extended in the clarifying the probable mode of action of Tribulus terrestris steroid saponins.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Androgens / biosynthesis*
  • Androstenedione / biosynthesis
  • Humans
  • Luteinizing Hormone / biosynthesis
  • Male
  • Plant Extracts / pharmacology*
  • Prostate / drug effects
  • Prostate / pathology
  • Sexual Behavior / drug effects
  • Testosterone / biosynthesis
  • Tribulus*

Substances

  • Androgens
  • Plant Extracts
  • Testosterone
  • Androstenedione
  • Luteinizing Hormone