Attenuation of preoptic area glutamate release correlates with reduced luteinizing hormone secretion in middle-aged female rats

Endocrinology. 2005 Oct;146(10):4331-9. doi: 10.1210/en.2005-0575. Epub 2005 Jun 30.

Abstract

Glutamate (Glu) and its receptors are involved in the maturation and maintenance of the neural mechanisms governing the preovulatory LH surge of young, reproductive-aged rodents and nonhuman primates. Little is known about the role of Glu in the delayed onset and reduced peak amplitude of the LH surge that characterizes female rodents during early reproductive senescence. The present study tested the hypothesis that the delayed and attenuated LH surge observed in middle-aged female rats is associated with altered hypothalamic Glu release. We used intracerebral microdialysis in young (3-4 months) and middle-aged (9-11 months) female rats to monitor changes in medial preoptic area Glu release and jugular vein catheters to monitor changes in serum LH levels. All animals were ovariectomized and injected with estradiol and progesterone in doses sufficient to produce a robust LH surge in most (approximately 70%) young rats. In both young and middle-aged females that surged, extracellular Glu levels were higher than in those that did not surge. Among animals that surged, the onset of the LH surge was significantly delayed, and the amplitude of the surge was significantly reduced in middle-aged compared with young rats. Middle-aged females also had significantly reduced extracellular Glu levels throughout the day of the LH surge when compared with young females. These data strongly suggest that age-related hypothalamic dysfunction contributes to reproductive aging independent of gonadal failure. We propose that reduced medial preoptic area Glu transmission contributes to reproductive aging by attenuating excitatory input to GnRH neurons.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging
  • Animals
  • Female
  • Glutamic Acid / metabolism*
  • Hypothalamus / growth & development
  • Hypothalamus / metabolism
  • Luteinizing Hormone / metabolism*
  • Microdialysis
  • Periodicity
  • Preoptic Area / growth & development
  • Preoptic Area / metabolism*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Glutamic Acid
  • Luteinizing Hormone