Thematic review series: the pathogenesis of atherosclerosis: an interpretive history of the cholesterol controversy, part III: mechanistically defining the role of hyperlipidemia

J Lipid Res. 2005 Oct;46(10):2037-51. doi: 10.1194/jlr.R500010-JLR200. Epub 2005 Jul 1.


In this third installment of the series, we point out that the absence of an explicit, detailed and plausible hypothesis linking hypercholesterolemia to the events in the artery wall was probably an important reason for continuing skepticism and for failure to treat elevated blood cholesterol levels. The rapid advances in understanding of lipoprotein metabolism in the 1950s and 1960s and the application of modern cellular biology in the 1970s provided the context for a modern consensus on pathogenetic mechanisms of atherogenesis.

Publication types

  • Historical Article

MeSH terms

  • Animals
  • Arteriosclerosis / etiology
  • Arteriosclerosis / history*
  • Foam Cells / physiology
  • History, 19th Century
  • History, 20th Century
  • Humans
  • Hyperlipidemias / complications*
  • Lipoproteins / blood
  • National Institutes of Health (U.S.) / history
  • Platelet Aggregation
  • Receptors, LDL
  • United States


  • Lipoproteins
  • Receptors, LDL