Anticentromere antibody as a predictor of digital ischemic loss in patients with systemic sclerosis

Arthritis Rheum. 1992 Jun;35(6):688-93. doi: 10.1002/art.1780350614.


Objective: To determine the clinical and serologic risk factors for digital ischemic events in patients with systemic sclerosis (SSc).

Methods: Retrospective review of clinical and laboratory data and review of current clinical status of 98 patients with SSc, seen between 1985 and 1990.

Results: Amputation of 1 or more digits due to ischemia occurred in 20.4% of the patients; 9.2% had multiple digit loss. Sclerodactyly alone and anticentromere antibody (ACA) were associated with loss of 1 or more digits. Age, smoking status, duration of disease, or duration of Raynaud's phenomenon were not predictive for loss of digits.

Conclusion: Patients with limited SSc who are positive for ACA have an increased risk of major peripheral vascular occlusive disease.

MeSH terms

  • Adult
  • Aged
  • Antibodies / analysis*
  • Centromere / immunology*
  • Fingers / blood supply*
  • Humans
  • Ischemia / complications*
  • Middle Aged
  • Models, Statistical
  • Respiratory Function Tests
  • Scleroderma, Systemic / complications
  • Scleroderma, Systemic / diagnosis
  • Scleroderma, Systemic / immunology*
  • Smoking


  • Antibodies