Synchronous endometrial and cervical tumors in a 26-year-old nullipara: diagnostic modalities updated

Gynecol Obstet Invest. 2005;60(3):171-6. doi: 10.1159/000086706. Epub 2005 Jul 1.


Proton magnetic resonance spectroscopy (MRS), performed on conventional magnetic resonance imaging (MRI) scanners, provides useful information at the biochemical level. MRS has been used to measure tissue concentrations of proton-containing compounds such as organic and amino acids, and sugars in living tissues. We have used MRS in a 26-year-old female with suspected cervical and endometrial carcinomas. With the use of the above mentioned technique, biochemical differences in the endometrium and the cervix tissues were detected. The presented case is the first virgin patient in the relevant literature in whom endometrial and cervical carcinoma was detected. Choline (Cho), creatine (Cr), N-acetylaspartate (NAA), lipid and lactate region of the MRS spectrum suggested that the technique could be used as an indicator of metabolic alterations in the cervical and endometrial tumor cells.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers, Tumor / analysis
  • Endometrial Neoplasms / chemistry
  • Endometrial Neoplasms / diagnosis*
  • Endometrial Neoplasms / pathology
  • Female
  • Humans
  • Immunohistochemistry
  • Leiomyoma / diagnosis*
  • Leiomyoma / metabolism
  • Leiomyoma / pathology
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • Neoplasms, Multiple Primary / chemistry
  • Neoplasms, Multiple Primary / diagnosis*
  • Neoplasms, Multiple Primary / pathology
  • Parity*
  • Pregnancy
  • Sexual Abstinence
  • Uterine Cervical Neoplasms / chemistry
  • Uterine Cervical Neoplasms / diagnosis*
  • Uterine Cervical Neoplasms / pathology


  • Biomarkers, Tumor