A polymorphism in the apolipoprotein A5 gene is associated with weight loss after short-term diet

Clin Genet. 2005 Aug;68(2):152-4. doi: 10.1111/j.1399-0004.2005.00463.x.


Apolipoprotein A5 is a recently discovered apolipoprotein involved primarily in triglyceride metabolism. Several single-nucleotide polymorphisms have been investigated since the initial report. The -1131T>C polymorphism has been associated with higher triglyceride levels and a decreased high-density lipoprotein cholesterol as well as with susceptibility to coronary heart disease. However, no study has so far emphasized on the association of a dietary intervention with apolipoprotein A5 polymorphisms. In a group of 606 hyperlipaemic and overweight men, we investigated how a short-term fat restriction affects lipid traits and body mass index (BMI) in wildtype and carriers of the -1131T>C polymorphism. Our result was that the reduction of BMI was significantly higher in C allele carriers (p=0.0021). Since the -1131T>C polymorphism predisposes to coronary heart disease, a restriction diet is an important therapeutic approach in -1131T>C carriers.

MeSH terms

  • Adult
  • Apolipoprotein A-V
  • Apolipoproteins / genetics*
  • Apolipoproteins A
  • Body Mass Index
  • Cholesterol / blood
  • Diet, Reducing
  • Dietary Fats
  • Humans
  • Male
  • Middle Aged
  • Obesity / diet therapy*
  • Obesity / genetics*
  • Polymorphism, Single Nucleotide*
  • Risk Factors
  • Triglycerides / blood
  • Weight Loss / genetics*


  • APOA5 protein, human
  • Apolipoprotein A-V
  • Apolipoproteins
  • Apolipoproteins A
  • Dietary Fats
  • Triglycerides
  • Cholesterol