G1 events and the regulation of genes for S-phase enzymes

Curr Opin Cell Biol. 1992 Apr;4(2):149-54. doi: 10.1016/0955-0674(92)90025-8.


The genes for S-phase enzymes are expressed at low levels in quiescent mammalian cells but at high levels during DNA replication. Regulation occurs at multiple levels by mechanisms that are different for each gene. Current research is focused on identifying the control elements and trans-acting factors for each gene and establishing relationships between these regulatory mechanisms and the G1 signal transduction pathway.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / genetics*
  • Cell Cycle / physiology
  • DNA-Directed DNA Polymerase / genetics
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Tetrahydrofolate Dehydrogenase / genetics
  • Thymidine Kinase / genetics
  • Thymidylate Synthase / genetics


  • Tetrahydrofolate Dehydrogenase
  • Thymidylate Synthase
  • Thymidine Kinase
  • DNA-Directed DNA Polymerase