Scaffold proteins dictate Rho GTPase-signaling specificity

Trends Biochem Sci. 2005 Aug;30(8):423-6. doi: 10.1016/j.tibs.2005.06.006.


Given the numerous mechanisms that regulate the activity of Rho GTPases and the multiple effectors for Rho proteins, how is specificity achieved when transducing signals via Rho GTPase-regulated molecular networks? The finding that the scaffold protein hCNK1 links Rho guanine-nucleotide-exchange factors and Rho to JNK (c-Jun N-terminal kinase), while limiting stress-fiber formation and serum-response-factor activation, suggests that scaffold proteins govern the selection of signal outputs, thus helping to solve the Rho GTPase-signaling puzzle.

MeSH terms

  • Animals
  • Cytoskeleton / metabolism
  • Gene Expression Regulation
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Signal Transduction*
  • Substrate Specificity
  • rho GTP-Binding Proteins / metabolism*


  • CNKSR1 protein, human
  • Intracellular Signaling Peptides and Proteins
  • rho GTP-Binding Proteins