Novel synthesis and anti-inflammatory activities of 2,5-disubstituted-dioxacycloalkanes

Lanrong Bi; Yue Zhang; Ming Zhao; Chao Wang; Priscilla Chan; Jeffrey B-H Tok; Shiqi Peng

doi:10.1016/j.bmc.2005.05.032

Novel synthesis and anti-inflammatory activities of 2,5-disubstituted-dioxacycloalkanes

Bioorg Med Chem. 2005 Oct 1;13(19):5640-6. doi: 10.1016/j.bmc.2005.05.032.

Authors

Lanrong Bi¹, Yue Zhang, Ming Zhao, Chao Wang, Priscilla Chan, Jeffrey B-H Tok, Shiqi Peng

Affiliation

¹ College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing 100054, PR China.

PMID: 15996872
DOI: 10.1016/j.bmc.2005.05.032

Abstract

A novel stereospecific synthetic route to obtain a series of 2,5-disubstituted-dioxacycloalkanes is reported. Using an in vivo inhibition assay by monitoring xylene-induced ear edema in mice, the structure-activity relationship of the dioxacycloalkane compounds was studied, and compounds possessing high anti-inflammatory activity were identified.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Anti-Inflammatory Agents / chemical synthesis*
Anti-Inflammatory Agents / pharmacology*
Cycloparaffins / chemical synthesis*
Cycloparaffins / pharmacology*
Ear Diseases / chemically induced
Ear Diseases / prevention & control
Edema / chemically induced
Edema / prevention & control
Male
Mice
Mice, Inbred Strains
Molecular Conformation
Stereoisomerism
Structure-Activity Relationship
Xylenes / antagonists & inhibitors
Xylenes / chemistry

Substances

Anti-Inflammatory Agents
Cycloparaffins
Xylenes