Mammalian stress response: induction of the glucose-regulated protein family

Curr Opin Cell Biol. 1992 Apr;4(2):267-73. doi: 10.1016/0955-0674(92)90042-b.


The glucose-regulated protein family consists of a set of stress-inducible proteins localized in the endoplasmic reticulum. Since their discovery in 1977, significant advances in our understanding of their structure, function and regulation have been made. Recent findings concerning the physiological roles played by the glucose-regulated proteins, and their regulations at the transcriptional, post-transcriptional, translational and post-translational levels are summarized.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation
  • HSP70 Heat-Shock Proteins*
  • Heat-Shock Proteins / genetics
  • Heat-Shock Proteins / physiology*
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Protein Biosynthesis
  • Protein Processing, Post-Translational
  • Transcription, Genetic


  • HSP70 Heat-Shock Proteins
  • Heat-Shock Proteins
  • Membrane Proteins
  • glucose-regulated proteins