Association of the G-463A myeloperoxidase polymorphism with infection in sickle cell anemia

Haematologica. 2005 Jul;90(7):977-9.

Abstract

Infections constitute a principal cause of morbidity and mortality in sickle cell anemia (SCA). Here we present evidence to suggest that a polymorphism (G-463A MPO) in the gene encoding the myeloperoxidase (MPO) enzyme, important for the host defense system, may significantly increase susceptibility to infection in SCA.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anemia, Sickle Cell / genetics*
  • Anemia, Sickle Cell / microbiology*
  • Child
  • Genetic Predisposition to Disease*
  • Humans
  • Infections / genetics
  • Middle Aged
  • Peroxidase / genetics*
  • Polymorphism, Genetic*

Substances

  • Peroxidase