Intracerebroventricular Self-Administration of Commonly Abused Anabolic-Androgenic Steroids in Male Hamsters (Mesocricetus Auratus): Nandrolone, Drostanolone, Oxymetholone, and Stanozolol

Behav Neurosci. 2005 Jun;119(3):752-8. doi: 10.1037/0735-7044.119.3.752.

Abstract

Previous studies by the authors have shown voluntary intracerebroventricular (icv) testosterone self-administration in hamsters (Mesocricetus auratus). Here, the authors compared icv self-administration of 4 anabolic steroids (drostanolone, nandrolone, oxymetholone, and stanozolol) at 0.1, 1.0, and 2.0 microg/microl, each for 8 days. Males (n=8/group) showed the highest levels of operant behavior for injectable steroids (drostanolone, nandrolone) compared with orally active androgens (oxymetholone, stanozolol). For nandrolone, responses on the active and inactive nose-pokes averaged 22.3 +/- 4.6/4 hr and 10.7 +/- 2.0/4 hr, respectively. Responding for drostanolone was similar. Males self-administering oxymetholone or stanozolol did not prefer the active nose-poke. These data demonstrate that injectable androgens are more reinforcing than oral steroids.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analysis of Variance
  • Androgens / administration & dosage*
  • Androstanols / administration & dosage
  • Animals
  • Behavior, Animal / drug effects
  • Conditioning, Operant / drug effects*
  • Cricetinae
  • Dose-Response Relationship, Drug
  • Drug Administration Routes
  • Exploratory Behavior / drug effects
  • Injections, Intraventricular
  • Male
  • Nandrolone / administration & dosage
  • Oxymetholone / administration & dosage
  • Reinforcement, Psychology*
  • Self Administration / methods
  • Stanozolol / administration & dosage
  • Substance-Related Disorders / physiopathology*
  • Time Factors

Substances

  • Androgens
  • Androstanols
  • Stanozolol
  • Nandrolone
  • dromostanolone
  • Oxymetholone