Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human

Genome Biol. 2005;6(7):R60. doi: 10.1186/gb-2005-6-7-r60. Epub 2005 Jun 30.


We report the initial sequencing and comparative analysis of the Macaca mulatta transcriptome. Cloned sequences from 11 tissues, nine animals, and three species (M. mulatta, M. fascicularis, and M. nemestrina) were sampled, resulting in the generation of 48,642 sequence reads. These data represent an initial sampling of the putative rhesus orthologs for 6,216 human genes. Mean nucleotide diversity within M. mulatta and sequence divergence among M. fascicularis, M. nemestrina, and M. mulatta are also reported.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA Primers
  • DNA, Complementary / genetics
  • Databases, Nucleic Acid
  • Evolution, Molecular
  • Gene Library
  • Genetic Variation*
  • Humans / genetics*
  • Macaca fascicularis / genetics
  • Macaca mulatta*
  • Macaca nemestrina / genetics
  • Oligonucleotide Array Sequence Analysis
  • Sequence Homology, Nucleic Acid
  • Transcription, Genetic*


  • DNA Primers
  • DNA, Complementary