Conservation anchors in the vertebrate genome

Genome Biol. 2005;6(7):115. doi: 10.1186/gb-2005-6-7-115. Epub 2005 Jun 29.


Genomic segments that do not code for proteins yet show high conservation among vertebrates have recently been identified by various computational methodologies. We refer to them as ANCORs (ancestral non-coding conserved regions). The frequency of individual ANCORs within the genome, along with their (correlated) inter-species identity scores, helps in assessing the probability that they function in transcription regulation or RNA coding.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Conserved Sequence
  • Genetic Code
  • Genetic Variation
  • Genome*
  • Vertebrates / genetics*