Chemokine receptor internalization and intracellular trafficking

Cytokine Growth Factor Rev. 2005 Dec;16(6):637-58. doi: 10.1016/j.cytogfr.2005.05.008. Epub 2005 Jul 5.


The internalization and intracellular trafficking of chemokine receptors have important implications for the cellular responses elicited by chemokine receptors. The major pathway by which chemokine receptors internalize is the clathrin-mediated pathway, but some receptors may utilize lipid rafts/caveolae-dependent internalization routes. This review discusses the current knowledge and controversies regarding these two different routes of endocytosis. The functional consequences of internalization and the regulation of chemokine receptor recycling will also be addressed. Modifications of chemokine receptors, such as palmitoylation, ubiquitination, glycosylation, and sulfation, may also impact trafficking, chemotaxis and signaling. Finally, this review will cover the internalization and trafficking of viral and decoy chemokine receptors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement*
  • Clathrin-Coated Vesicles / physiology*
  • Endocytosis*
  • Humans
  • Membrane Microdomains / physiology
  • Protein Transport / physiology
  • Receptors, Chemokine / metabolism
  • Receptors, Chemokine / physiology*
  • rab GTP-Binding Proteins / physiology


  • Receptors, Chemokine
  • rab GTP-Binding Proteins