Effect of treatment with cisapride alone or in combination with domperidone on gastric emptying and gastrointestinal symptoms in dyspeptic patients

Aliment Pharmacol Ther. 1992 Apr;6(2):221-8. doi: 10.1111/j.1365-2036.1992.tb00265.x.


The effects on gastric emptying and gastrointestinal symptoms of treatment with cisapride alone and in combination with domperidone were investigated in 25 patients with chronic idiopathic dyspepsia. In a double-blind study, 9 patients were randomly assigned to receive cisapride 2.5 mg three times daily, and 8 patients to receive placebo. After 7 days of treatment, gastric emptying was significantly accelerated and the score of gastrointestinal symptoms was significantly reduced in patients treated with cisapride. Placebo treatment had no significant effect. A randomized, double-blind crossover study of 8 patients compared the effects of combined treatment with cisapride 2.5 mg plus domperidone 10 mg three times daily for 7 days against the effects of cisapride plus placebo. Administration of cisapride plus domperidone gave significantly higher gastric emptying and lower gastrointestinal symptoms than cisapride plus placebo.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Chronic Disease
  • Cisapride
  • Domperidone / pharmacology*
  • Double-Blind Method
  • Drug Therapy, Combination
  • Dyspepsia / drug therapy*
  • Dyspepsia / physiopathology
  • Female
  • Gastric Emptying / drug effects*
  • Humans
  • Male
  • Middle Aged
  • Piperidines / pharmacology*
  • Serotonin Antagonists / pharmacology*


  • Piperidines
  • Serotonin Antagonists
  • Domperidone
  • Cisapride