Characterization of a novel P[25],G11 human group a rotavirus

J Clin Microbiol. 2005 Jul;43(7):3208-12. doi: 10.1128/JCM.43.7.3208-3212.2005.

Abstract

A novel rotavirus strain (Dhaka6) isolated from a 21-year-old Bangladeshi male patient was characterized by sequence analysis of its VP7 and VP4 gene segments. Phylogenetic analysis of the VP7 gene of the Dhaka6 strain revealed a common evolutionary lineage with porcine G11 rotavirus strains. This isolate is the first reported G11 rotavirus strain infecting a human host. Comparison of the VP4 gene sequences with all currently recognized 24 different P genotypes revealed only low nucleotide (54 to 71%) and amino acid (52 to 76%) sequence identities. This lack of high sequence similarity in the VP4 gene indicates that the Dhaka6 isolate represents a new group A rotavirus P genotype, to which we propose assignment of the designation P[25].

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Animals
  • Antigens, Viral / genetics
  • Capsid Proteins / genetics
  • Cattle
  • DNA, Viral / analysis
  • Genotype
  • Humans
  • Male
  • Mice
  • Molecular Sequence Data
  • Phylogeny
  • Rotavirus / classification*
  • Rotavirus / genetics*
  • Rotavirus / isolation & purification
  • Rotavirus Infections / virology*
  • Sequence Analysis, DNA

Substances

  • Antigens, Viral
  • Capsid Proteins
  • DNA, Viral
  • VP4 protein, Rotavirus
  • VP7 protein, Rotavirus

Associated data

  • GENBANK/AY773003
  • GENBANK/AY773004