How and when to use mitomycin-C in refractive surgery

Curr Opin Ophthalmol. 2005 Aug;16(4):256-9. doi: 10.1097/


Purpose of review: Mitomycin-C is an antimetabolite that has seen increased use in ophthalmology over the past several decades. From glaucoma surgery to the management of various corneal disorders, mitomycin-C seems to be a viable tool in the management of scar and haze formation.

Recent findings: With the constant evolution of refractive surgery, mitomycin-C has come to the forefront as a modulator of corneal wound healing after excimer laser surface ablation.

Summary: This article will describe the various indications, techniques, and current trends of mitomycin-C application in corneal refractive surgery.

Publication types

  • Review

MeSH terms

  • Antibiotics, Antineoplastic / therapeutic use*
  • Cornea / surgery*
  • Corneal Surgery, Laser
  • Humans
  • Mitomycin / therapeutic use*
  • Refractive Surgical Procedures*
  • Wound Healing / drug effects


  • Antibiotics, Antineoplastic
  • Mitomycin