Histologic evaluation of mineralized and demineralized freeze-dried bone allograft for ridge and sinus augmentations

Int J Periodontics Restorative Dent. 2005 Jun;25(3):231-7.


The objective of this study was to quantify new bone formation from biopsies of demineralized freeze-dried bone allograft (DFDBA) and freeze-dried bone allograft (FDBA) following ridge and sinus augmentations. Ninety-three patients who received maxillary sinus or ridge augmentation grafts agreed to core biopsies of their grafts when the implants were placed. Samples ranged from 6 to 36 months postgrafting. These samples were sectioned, stained, and examined histomorphometrically Seventy-two FDBA and 21 DFDBA samples were examined, and the mean percentages of new bone formed were 41.89% and 41.74%, respectively. There was no statistical difference, irrespective of graft site.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Alveolar Ridge Augmentation / methods
  • Biopsy
  • Bone Demineralization Technique
  • Bone Matrix / transplantation*
  • Bone Regeneration*
  • Bone Transplantation / methods*
  • Female
  • Freeze Drying
  • Humans
  • Male
  • Maxillary Sinus / surgery
  • Middle Aged
  • Oral Surgical Procedures, Preprosthetic / methods*
  • Retrospective Studies
  • Statistics, Nonparametric