Lung cancer in women: emerging differences in epidemiology, biology, and therapy

Chest. 2005 Jul;128(1):370-81. doi: 10.1378/chest.128.1.370.


Lung cancer is the major cause of cancer-related death in both men and women in the United States. Emerging evidence indicates that there are differences in the pathogenesis and possibly increased susceptibility to lung cancer in women. In addition, considerable data support small, but important differences favoring women in terms of response to therapy and long-term survival after the diagnosis of lung cancer, regardless of histology or stage. These differences in both biology and outcome will be important considerations in the design of future trials of screening and therapy for lung cancer.

Publication types

  • Review

MeSH terms

  • Disease Susceptibility
  • Estrogen Replacement Therapy / adverse effects
  • Estrogens / adverse effects
  • Female
  • Humans
  • Lung Neoplasms* / epidemiology
  • Lung Neoplasms* / genetics
  • Lung Neoplasms* / pathology
  • Lung Neoplasms* / therapy
  • Prevalence
  • Risk Factors
  • Sex Factors
  • United States / epidemiology
  • Women's Health*


  • Estrogens