Early loss of two renal grafts obtained from the same donor: role of ecstasy?

Transplantation. 2005 Jul 15;80(1):153-6. doi: 10.1097/01.tp.0000158713.70266.06.


Early loss of renal grafts is generally caused by vascular or immunologic complications. We describe two patients who received a kidney transplant from the same donor and lost their grafts during the first posttransplant week. Both cases presented necrotizing graft vasculopathy without inflammatory element. The donor was a 21-year-old woman who regularly used "ecstasy" over a 2-year period. After an extensive work-up to investigate the potential causes of graft loss, we considered the possibility of ecstasy being the cause of these two renal-graft losses.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Glomerulonephritis, IGA / complications
  • Hallucinogens / toxicity*
  • Histocompatibility Testing
  • Humans
  • Infarction / pathology
  • Kidney / pathology
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation / pathology*
  • Male
  • N-Methyl-3,4-methylenedioxyamphetamine / toxicity*
  • Renal Circulation
  • Thrombosis / pathology
  • Tissue Donors*
  • Treatment Failure


  • Hallucinogens
  • N-Methyl-3,4-methylenedioxyamphetamine