Creatine monohydrate supplementation does not improve functional recovery after total knee arthroplasty

Arch Phys Med Rehabil. 2005 Jul;86(7):1293-8. doi: 10.1016/j.apmr.2005.01.005.


Objective: To determine if creatine monohydrate supplementation can improve body composition and enhance recovery after total knee arthroplasty (TKA).

Design: Randomized trial in which creatine monohydrate or placebo was administered.

Setting: Public primary care facility.

Participants: Thirty-seven adults (17 men, 20 women) with osteoarthritis undergoing TKA. Intervention Subjects received creatine monohydrate (10 g/d x 10 d presurgery to 5 g/d x 30 d postsurgery) or placebo.

Main outcome measures: Body composition (dual-energy x-ray absorptiometry scanning), muscle metabolite concentrations (adenosine triphosphate, phosphocreatine, creatine, total creatine [phosphocreatine + creatine]), muscle histomorphometery, quadriceps, ankle dorsiflexion and handgrip strength, and functional capacity. All measurements were completed preoperatively (-7 d) and 30 days postoperatively, except for that of muscle metabolites. Muscle metabolite samples were collected during surgery (0 d) and at 30 days.

Results: A significant decrease in quadriceps and ankle dorsiflexion strength was observed at 30 days postoperatively (P < .01). There were no significant effects of creatine monohydrate supplementation on any of the measured outcome variables.

Conclusions: Creatine monohydrate supplementation did not improve body composition or muscle strength when given before surgery, nor did it enhance recovery after TKA.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthroplasty, Replacement, Knee*
  • Body Composition / physiology
  • Creatine / analysis
  • Creatine / therapeutic use*
  • Double-Blind Method
  • Female
  • Hand Strength / physiology
  • Humans
  • Male
  • Middle Aged
  • Muscle, Skeletal / chemistry
  • Muscle, Skeletal / physiopathology
  • Osteoarthritis, Knee / surgery
  • Postoperative Care
  • Preoperative Care
  • Prospective Studies
  • Recovery of Function / physiology*


  • Creatine