Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients

J Neuroimmunol. 2005 Sep;166(1-2):197-201. doi: 10.1016/j.jneuroim.2005.06.002.


Chromosome region 2q33 encodes several regulators of the immune system, among these the CD28, CTLA4, and ICOS molecules. Involvement of these genes in multiple sclerosis (MS) is not yet clear. We investigated six microsatellites and three SNPs in a relatively large and clinically well characterised Norwegian MS cohort. No associations were observed for any of the markers analysed in 575 MS patients and 551 controls. Associations were neither found when stratifying the material for the HLA-DRB1*1501, DQB1*0602 haplotype, gender, age at onset, disease course nor familial aggregation. In conclusion, this study could not confirm association with the CD28/CTLA4/ICOS gene region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antigens, CD
  • Antigens, Differentiation / genetics*
  • Antigens, Differentiation, T-Lymphocyte / genetics*
  • CD28 Antigens / genetics*
  • CTLA-4 Antigen
  • Case-Control Studies
  • Child
  • Cohort Studies
  • Female
  • Genotype
  • HLA-DQ Antigens / genetics
  • HLA-DQ beta-Chains
  • HLA-DR Antigens / genetics
  • HLA-DRB1 Chains
  • Haplotypes
  • Humans
  • Inducible T-Cell Co-Stimulator Protein
  • Male
  • Membrane Glycoproteins / genetics
  • Microsatellite Repeats
  • Middle Aged
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / immunology*
  • Norway
  • Polymorphism, Single Nucleotide


  • Antigens, CD
  • Antigens, Differentiation
  • Antigens, Differentiation, T-Lymphocyte
  • CD28 Antigens
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • HLA-DQ Antigens
  • HLA-DQ beta-Chains
  • HLA-DQB1 antigen
  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • HLA-DRB1*15:01 antigen
  • ICOS protein, human
  • Inducible T-Cell Co-Stimulator Protein
  • Membrane Glycoproteins