Integrins and Src: Dynamic Duo of Adhesion Signaling

Trends Cell Biol. 2005 Aug;15(8):399-403. doi: 10.1016/j.tcb.2005.06.005.

Abstract

Src family protein tyrosine kinases (SFKs) play important roles downstream of integrin adhesion receptors, and they are necessary for the generation of "outside-in signals" that regulate cytoskeletal organization, cell motility and gene expression in response to cell adhesion. One relatively under-explored facet of this relationship is the possible physical interaction of integrins with SFKs. Recently, it has been established that beta3 integrins and c-Src can interact directly, and this pool of c-Src is activated by cell adhesion to initiate outside-in signaling in platelets, osteoclasts and cells of the vasculature. Here, the biochemical basis for and biological significance of this integrin-SFK interaction is summarized, and I propose a general mechanism for initiation of outside-in integrin signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Adhesion
  • Integrins / metabolism*
  • Models, Biological
  • Protein Binding
  • Signal Transduction*
  • src-Family Kinases / metabolism*

Substances

  • Integrins
  • src-Family Kinases