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Multicenter Study
, 43 (3), 508-14

Prevalence of and Risk Factors for Fatty Liver in a General Population of Shanghai, China

Multicenter Study

Prevalence of and Risk Factors for Fatty Liver in a General Population of Shanghai, China

Jian-Gao Fan et al. J Hepatol.


Background/aims: To determine the prevalence and risk factors of fatty liver (FL) among Shanghai adults.

Methods: A cross-sectional ultrasonographic survey with randomized multistage stratified cluster sampling was used.

Results: The study included 3175 subjects (1218 men) with a mean age of 52 years. FL was found in 661 (20.82%) subjects. After adjustment by age and sex, FL prevalence was found to be 17.29%, and the prevalences of alcoholic, suspected alcoholic and nonalcoholic FL were determined to be 0.79, 1.15 and 15.35%, respectively. Generally, age, body mass index (BMI), waist circumference, blood pressure, and the prevalences of obesity, diabetes, hypertension and dyslipidemia were all significantly higher in FL patients than in controls; In contrast, the levels of high-density-lipoprotein cholesterol (HDL-C), education and physical activity were markedly lower. Multiple regression analyses showed that only nine factors (male, educational level, waist circumference, BMI, HDL-C, triglyceride, fasting plasma glucose, diabetes and hypertension) were closely related to FL. In excessive drinkers, obesity increased the risk for FL by 4.8-fold, but excessive drinking was associated with only a 1.5-fold increased risk in obese subjects.

Conclusions: FL in Shanghai is highly prevalent and mainly related to multiple metabolic disorders.

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