[Post-haemodilution anaemia in paediatric cardiac surgery: benefit of intravenous iron therapy]

Ann Fr Anesth Reanim. 2005 Oct;24(10):1262-5. doi: 10.1016/j.annfar.2005.05.023. Epub 2005 Jul 11.
[Article in French]


Objective: Anaemia is the main complication following haemodilution in paediatric cardiac surgery. Iron oral therapy is ineffective to improve anaemia. The aim of this study is to assess the effect of a single dose of intravenous iron saccharate Venofer.

Study design: Open, randomized.

Patients and methods: 93 patients were randomized in two groups. The first one is the control group without iron supplementation and the second one received a 5 mg/kg injection of Venofer administered at day 1. Three biological factors were studied on day 1 and day 5 following surgery: haemoglobin, ferrritin and reticulocyte rate. Student test was used for statistical analysis of results.

Results: Age, weight, haemoglobin, ferritine and reticulocyte on day 1 were similar in both group (no significant difference). On day 5 ferritin was higher in the treated group 215+/-87 vs 101+/-55 mug/l in the non treated group (P<0.001). Reticulocyte rate was also higher in the treated group 3.25+/-1.16 vs 2.65+/-0.97% (P<0.005) in the untreated group.

Conclusion: Postoperative systemic inflammation is probably the factor which impaired the effect of oral iron therapy. Parenteral iron may act by treating a functional iron deficiency and/or by increasing endogenous erythropoietin synthesis. Faster reversibility of anaemia following iron injection improves quality of the postoperative recovery.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Anemia / drug therapy*
  • Anemia / etiology*
  • Cardiac Surgical Procedures / adverse effects*
  • Child
  • Child, Preschool
  • Female
  • Ferric Compounds / administration & dosage
  • Ferric Compounds / therapeutic use*
  • Ferric Oxide, Saccharated
  • Ferritins / blood
  • Glucaric Acid
  • Hemodilution / adverse effects*
  • Hemoglobins / metabolism
  • Humans
  • Infant
  • Infusions, Intravenous
  • Male
  • Postoperative Complications / drug therapy*
  • Postoperative Complications / etiology*
  • Reticulocyte Count
  • Sucrose / administration & dosage
  • Sucrose / therapeutic use*


  • Ferric Compounds
  • Hemoglobins
  • Sucrose
  • Ferritins
  • Ferric Oxide, Saccharated
  • Glucaric Acid