Cortical calcium waves in resting newborn mice

Nat Neurosci. 2005 Aug;8(8):988-90. doi: 10.1038/nn1502. Epub 2005 Jul 10.


Using a new optical fiber-based approach, we demonstrate the presence of recurrent Ca(2+) transients in cortical neurons of non-anesthetized newborn mice in vivo. These Ca(2+) waves reflect the correlated activity of thousands of cells and were detected only in resting, but not in moving pups. Our results suggest that Ca(2+)-dependent cortical maturation occurs predominantly during the intermittent sleep-like resting periods that are characteristic for the first days of postnatal life.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aniline Compounds
  • Animals
  • Animals, Newborn / metabolism*
  • Calcium / metabolism*
  • Cerebral Cortex / cytology
  • Cerebral Cortex / metabolism*
  • Fiber Optic Technology
  • Fluoresceins
  • Fluorescent Dyes
  • Mice
  • Neurons / metabolism
  • Optical Fibers
  • Oscillometry
  • Photons
  • Rest / physiology*


  • Aniline Compounds
  • Fluoresceins
  • Fluorescent Dyes
  • Oregon green 488 BAPTA-1
  • Calcium