Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1

Nat Neurosci. 2005 Aug;8(8):985-7. doi: 10.1038/nn1432. Epub 2005 Jul 10.


The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Hippocampus / physiology*
  • Ligands*
  • Long-Term Potentiation / physiology*
  • Long-Term Synaptic Depression / physiology
  • Mice
  • Mice, Transgenic
  • Neuronal Plasticity / physiology
  • Receptors, AMPA / metabolism*
  • Synapses / metabolism
  • Synaptic Transmission / physiology
  • Tissue Distribution


  • Ligands
  • Receptors, AMPA
  • glutamate receptor ionotropic, AMPA 1