Hypoxia-responsive transcription factors

Pflugers Arch. 2005 Sep;450(6):363-71. doi: 10.1007/s00424-005-1413-7. Epub 2005 Jul 9.


Hypoxia is a common pathophysiological occurrence with a profound impact on the cellular transcriptome. The consequences of hypoxia-induced or hypoxia-repressed gene expression have important implications in disease processes as diverse as tumour development and chronic inflammation. While the hypoxia-inducible factor (HIF-1) plays a major role in controlling the ubiquitous transcriptional response to hypoxia, it is clear that a number of other transcription factors are also activated either directly or indirectly. In this review, we comprehensively discuss the transcription factors that have been reported to be hypoxia-responsive and the signalling mechanisms leading to their activation. Understanding such events will enhance our understanding of cellular oxygen sensing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Protein-beta / physiology
  • Cell Hypoxia / physiology
  • Cyclic AMP Response Element-Binding Protein / physiology
  • Early Growth Response Protein 1 / physiology
  • Humans
  • Hypoxia / physiopathology*
  • Hypoxia-Inducible Factor 1 / physiology
  • NF-kappa B / physiology
  • Sp1 Transcription Factor / physiology
  • Sp3 Transcription Factor / physiology
  • Transcription Factor AP-1 / physiology
  • Transcription Factors / physiology*
  • Tumor Suppressor Protein p53 / physiology


  • CCAAT-Enhancer-Binding Protein-beta
  • Cyclic AMP Response Element-Binding Protein
  • Early Growth Response Protein 1
  • Hypoxia-Inducible Factor 1
  • NF-kappa B
  • Sp1 Transcription Factor
  • Transcription Factor AP-1
  • Transcription Factors
  • Tumor Suppressor Protein p53
  • Sp3 Transcription Factor