Relationship between breath-hold time and physical performance in patients with cystic fibrosis

Eur J Appl Physiol. 2005 Oct;95(2-3):172-8. doi: 10.1007/s00421-005-1350-3. Epub 2005 Jul 9.


Rehabilitation including physiotherapy is an important part of the treatment used to help improve the quality of life of patients with cystic fibrosis (CF). The aim of this study was to determine the value of the breath-hold time as an index of exercise tolerance in patients with CF. Eighteen patients in different states of CF were included. The breath-hold time was measured in all patients. The fitness level was assessed by means of a progressive exercise test on a cycle-ergometer. During the test, oxygen uptake (VO(2)) and carbon dioxide elimination (VCO(2)) were measured breath by breath. The VO(2) and working capacity (WC) were computed at the anaerobic threshold (AT) and at peak. Duration of breath-hold was 24.7 +/- 2.87 (mean +/- SEM) seconds, varying between 10 and 58. The breath-hold time (BHT) displayed a significant correlation with VO(2) (r = 0.898), WC (r = 0.899) at the AT, and the peak VO(2) (r = 0.895). Regression equations were: VO(2) at the AT (ml/kg) = 5.53 + 0.42 x BHT and WC at the AT (watt/kg) = 0.56 + 0.38 x BHT Our results suggest that the voluntary breath-hold time might be a useful index for prediction of the exercise tolerance of CF patients.

MeSH terms

  • Adolescent
  • Adult
  • Anaerobic Threshold
  • Cystic Fibrosis / physiopathology*
  • Exercise Test
  • Exercise Tolerance / physiology*
  • Female
  • Humans
  • Male
  • Oxygen Consumption
  • Respiration*