Thymic carcinoma in children

Pediatr Blood Cancer. 2006 Aug;47(2):224-7. doi: 10.1002/pbc.20468.


Thymic epithelial neoplasms consist of thymomas, thymic carcinoids, and thymic carcinomas. Carcinomas are malignant tumors of the thymus characterized by obvious cytological anaplasia. They constitute only 4%-14% of thymic epithelial neoplams. Thymic carcinoma rarely occurs in children. Research in the English literature carried out for the present study revealed only 14 cases younger than 18 years-of-age. Here we have reported a 16-year old girl who presented with respiratory distress due to huge anterior mediastinal mass. Histological and immunohistochemical studies confirmed lymphoepithelioma-like thymic carcinoma. She received systemic chemotherapy and radiotherapy. However, she died within 15 months due to progressive disease.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols
  • Fatal Outcome
  • Female
  • Humans
  • Thymoma* / drug therapy
  • Thymoma* / pathology
  • Thymoma* / secondary
  • Thymus Neoplasms* / drug therapy
  • Thymus Neoplasms* / pathology
  • Tomography, X-Ray Computed