Human Cardiac Inflammatory Responses Triggered by Coxsackie B Viruses Are Mainly Toll-like Receptor (TLR) 8-dependent

Cell Microbiol. 2005 Aug;7(8):1117-26. doi: 10.1111/j.1462-5822.2005.00537.x.

Abstract

The group B coxsackieviruses are single-stranded RNA viruses that have been implicated in viral myocarditis. Viral infection of the myocardium, as well as the associated inflammatory response are important determinants of the virus-associated myocardial damage. Although these viruses are known as cytopathic viruses that cause death of the host cell, their viral RNA has been shown to persist in cardiac muscle contributing to a chronic inflammatory cardiomyopathy. Thus, it is essential that we understand the mechanism by which Coxasckie B viruses (CBVs) trigger this inflammatory response. In this study we investigated the involvement of Toll-like receptors (TLRs) in the recognition of CBV virions as well as CBV single-stranded RNA. Here we report that the CBV-induced inflammatory response is mediated through TLR8 and to a lesser extent through TLR7.

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism
  • Adult
  • Antigens, Differentiation / metabolism
  • Cells, Cultured
  • Coxsackievirus Infections / immunology*
  • Coxsackievirus Infections / virology
  • Cytokines / metabolism
  • Endosomes / metabolism
  • Enterovirus B, Human / physiology*
  • Female
  • Humans
  • Myeloid Differentiation Factor 88
  • Myocarditis / immunology*
  • Myocarditis / virology
  • Myocytes, Cardiac / metabolism*
  • Myocytes, Cardiac / virology
  • RNA Interference
  • RNA, Viral / metabolism
  • Receptors, Immunologic / metabolism
  • Toll-Like Receptor 7 / physiology
  • Toll-Like Receptor 8 / physiology*
  • Virion / physiology

Substances

  • Adaptor Proteins, Signal Transducing
  • Antigens, Differentiation
  • Cytokines
  • MYD88 protein, human
  • Myeloid Differentiation Factor 88
  • RNA, Viral
  • Receptors, Immunologic
  • TLR7 protein, human
  • TLR8 protein, human
  • Toll-Like Receptor 7
  • Toll-Like Receptor 8