Toxic epidermal necrolysis secondary to angioimmunoblastic T-cell lymphoma

Australas J Dermatol. 2005 Aug;46(3):187-91. doi: 10.1111/j.1440-0960.2005.00177.x.


A 67-year-old man presented with a history of lymphadenopathy, fevers and separate skin eruptions of erythrodermic spongiotic dermatitis initially and subsequent toxic epidermal necrolysis. Initial lymph node biopsies showed non-specific granulomatous changes, and skin biopsies and bone marrow aspirate were not diagnostic. His toxic epidermal necrolysis responded well to 3 days of intravenous immunoglobulin. The patient was discharged from hospital and reviewed regularly as an outpatient. Due to persisting lymphadenopathy, further lymph node biopsy led to the diagnosis of angioimmunoblastic T-cell lymphoma, a rare form of peripheral T-cell lymphoma with a poor prognosis. At the time of diagnosis his condition deteriorated rapidly and he died soon after.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Fatal Outcome
  • Head and Neck Neoplasms / complications*
  • Head and Neck Neoplasms / diagnosis
  • Humans
  • Immunoblastic Lymphadenopathy / complications*
  • Immunoblastic Lymphadenopathy / diagnosis
  • Immunoglobulins, Intravenous / therapeutic use
  • Lymph Nodes / pathology
  • Lymphoma, T-Cell / complications*
  • Lymphoma, T-Cell / diagnosis
  • Male
  • Stevens-Johnson Syndrome / diagnosis
  • Stevens-Johnson Syndrome / drug therapy
  • Stevens-Johnson Syndrome / etiology*


  • Immunoglobulins, Intravenous