Silence from within: endogenous siRNAs and miRNAs

Cell. 2005 Jul 15;122(1):9-12. doi: 10.1016/j.cell.2005.06.030.


Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechanisms of downregulation. Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands.

Publication types

  • Review

MeSH terms

  • Animals
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism
  • Gene Silencing*
  • Humans
  • MicroRNAs / genetics*
  • RNA, Small Interfering / genetics*


  • MicroRNAs
  • RNA, Small Interfering