Lindane-induced immunological alterations in human poisoning cases

Clin Biochem. 2005 Jul;38(7):678-80. doi: 10.1016/j.clinbiochem.2005.03.009.


Objectives: Evaluation of immunological alterations in the blood of human lindane poisoning cases.

Design and methods: Serum IgG, IgM, IgA, IgE, IL-2, IL-4, TNF-alpha, and IFN-gamma levels were measured using immunoassay in 20 human cases of lindane poisoning. The presence of lindane in blood was confirmed by HPLC.

Results: Serum IL-2, IL-4, and TNF-alpha levels were significantly raised with decrease in IFN-gamma levels in the lindane-exposed cases. Immunoglobulin levels were not altered.

Conclusions: The results suggest that lindane exposure at chronically high levels affects cytokine levels in humans and indicates the severity of immunotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibody Formation / drug effects*
  • Hexachlorocyclohexane / poisoning*
  • Immunity / drug effects*
  • Immunoglobulins / blood
  • Interferon-gamma / blood
  • Interleukin-2 / blood
  • Interleukin-4 / blood
  • Poisoning / immunology
  • Tumor Necrosis Factor-alpha / analysis


  • Immunoglobulins
  • Interleukin-2
  • Tumor Necrosis Factor-alpha
  • Interleukin-4
  • Hexachlorocyclohexane
  • Interferon-gamma