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Comparative Study
, 84 (1), 130-40

Sperm DNA Fragmentation Negatively Correlates With Velocity and Fertilization Rates but Might Not Affect Pregnancy Rates

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Comparative Study

Sperm DNA Fragmentation Negatively Correlates With Velocity and Fertilization Rates but Might Not Affect Pregnancy Rates

Chun-Chia Huang et al. Fertil Steril.

Abstract

Objective: To evaluate sperm DNA fragmentation in correlation with sperm parameters and IVF/intracytoplasmic sperm injection (ICSI) outcomes.

Design: Retrospective review.

Setting: A tertiary infertility referral clinic.

Patient(s): We collected 303 semen samples from patients undergoing IVF with or without ICSI.

Intervention(s): Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL) assay, measurement of fertilization rates, good embryo rates, and pregnancy rates for the IVF/ICSI program.

Main outcome measure(s): The percentage of sperm with DNA fragmentation, correlated with semen analysis parameters and IVF/ICSI outcomes.

Result(s): Sperm DNA fragmentation rates were significantly higher in patients with abnormal sperm parameters than in those with normal sperm parameters. When sperm DNA fragmentation was >10%, fertilization rates were affected. Sperm DNA fragmentation rates were negatively correlated with sperm velocity parameters but did not affect pregnancy outcomes.

Conclusion(s): The results indicated that sperm DNA fragmentation affects fertilization rates and sperm motility but might not affect pregnancy rates.

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