Abstract
The ATP-binding cassette transporter 1 (ABCA1) is a trans-membrane peptide that is involved in the lipidification of ApoA-I. ABCA1 gene was initially implicated in Tangier disease and familial hypoalphalipoproteinemia and has been shown to be associated with coronary artery disease and atherosclerosis as well. Recently, a haplotype in ABCA1 gene was associated with increased risk of type II diabetes mellitus (DM). In this report, a relationship between ApoA-I, DM and ABCA1 has been emphasized.
MeSH terms
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ATP Binding Cassette Transporter 1
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ATP-Binding Cassette Transporters / genetics*
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Apolipoprotein A-I / genetics*
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DNA Mutational Analysis / methods
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Diabetes Mellitus, Type 2 / epidemiology*
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Diabetes Mellitus, Type 2 / genetics
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Diabetes Mellitus, Type 2 / metabolism*
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Genetic Predisposition to Disease / epidemiology
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Genetic Testing / methods*
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Humans
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Incidence
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Polymorphism, Genetic*
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Risk Assessment / methods*
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Risk Factors
Substances
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ABCA1 protein, human
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ATP Binding Cassette Transporter 1
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ATP-Binding Cassette Transporters
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Apolipoprotein A-I