Hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil

R Wielgo-Polanin; L Lagarce; E Gautron; B Diquet; P Lainé-Cessac

doi:10.1016/j.ijantimicag.2005.04.019

Hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil

Int J Antimicrob Agents. 2005 Aug;26(2):176-8. doi: 10.1016/j.ijantimicag.2005.04.019.

Authors

R Wielgo-Polanin¹, L Lagarce, E Gautron, B Diquet, P Lainé-Cessac

Affiliation

¹ Centre Régional de Pharmacovigilance, Service de Pharmacologie et Toxicologie, CHU d'Angers, 4 rue Larrey, 49933 Angers Cedex 9, France.

PMID: 16009537
DOI: 10.1016/j.ijantimicag.2005.04.019

Abstract

Here we report on a case of hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil. Alternative causes of liver injury were excluded. The pathophysiological mechanism remains unclear, with a possibility of allergic reaction. In view of the widespread use of both drugs, clinicians should be aware of this drug-induced liver injury.

Publication types

Case Reports

MeSH terms

Adverse Drug Reaction Reporting Systems*
Antimalarials / administration & dosage
Antimalarials / adverse effects*
Chemical and Drug Induced Liver Injury*
Chloroquine / adverse effects*
Chloroquine / pharmacology
Drug Combinations
Drug Interactions
Female
Humans
Malaria, Falciparum / drug therapy
Malaria, Falciparum / prevention & control
Middle Aged
Proguanil / adverse effects*
Proguanil / pharmacology

Substances

Antimalarials
Drug Combinations
Chloroquine
Proguanil