Physiologically stable vanadium(IV) porphyrins as a new class of anti-HIV agents

Chem Commun (Camb). 2005 Jul 28;(28):3544-6. doi: 10.1039/b503535j. Epub 2005 Jun 1.

Abstract

The water soluble oxovanadium(IV) tetraarylporphyrin has demonstrated excellent solution stability against glutathione reduction and high potency (5 microM, 97% inhibition) in inhibiting HIV-1 replication in Hut/CCR5 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemistry*
  • Anti-HIV Agents / pharmacology
  • Cell Line
  • Dose-Response Relationship, Drug
  • Drug Stability
  • Glutathione / metabolism
  • Humans
  • Metalloporphyrins / chemistry
  • Metalloporphyrins / pharmacology*
  • Oxidation-Reduction
  • Receptors, CCR5
  • Solubility
  • Vanadium Compounds / chemistry
  • Vanadium Compounds / pharmacology*
  • Virus Replication / drug effects

Substances

  • Anti-HIV Agents
  • Metalloporphyrins
  • Receptors, CCR5
  • Vanadium Compounds
  • Glutathione