Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration

Expert Opin Drug Saf. 2005 Jul;4(4):779-94. doi: 10.1517/14740338.4.4.779.


This systematic review discusses the proposed uses, dosing parameters, adverse effects, toxicology, interactions and mechanism of action of kava. The widespread concern regarding the potential hepatotoxicity of kava is discussed. A recommendation is made to consolidate and analyse available reports and to continue postmarket surveillance in an international repository to prevent duplicates and promote collection of thorough details at the time of each report so that any association with kava is clearly defined.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Data Collection
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Humans
  • Kava / adverse effects*
  • Kava / chemistry*
  • Plant Preparations / adverse effects*
  • Plant Preparations / pharmacokinetics
  • Plant Preparations / pharmacology


  • Plant Preparations