Detection of Candida species in vaginal samples in a clinical laboratory setting

Infect Dis Obstet Gynecol. 2005 Jun;13(2):63-7. doi: 10.1080/10647440400025629.


Objective: To present the detection rates of Candida species in vaginal samples from patients visiting physicians.

Methods: The presence of C. albicans, C. glabrata, C. parapsilosis and C. tropicalis in 3978 vaginal swabs from patients in six US states was detected by PCR amplification.

Results: Candida DNA was detected in 33.1% of the population studied. Of the 1316 positive samples, 80.2% contained C. albicans, 14.3% contained C. glabrata, 5.9% contained C. parapsilosis and 8.0% contained C. tropicalis. Comparing samples by patients' state of residence revealed an association with the detection of C. glabrata (p = 0.029). Comparing samples by patients' age revealed a decrease in the overall detection of Candida (p < 0.001) and C. albicans (p < 0.001), concomitant with an increase in the detection of C. glabrata (p < 0.001) and C. parapsilosis (p = 0.025).

Conclusions: These results provide geographic- and age-specific data on four Candida species associated with vaginitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Candida / genetics
  • Candida / isolation & purification*
  • Candidiasis, Vulvovaginal / microbiology*
  • Child
  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • Female
  • Humans
  • Middle Aged
  • Polymerase Chain Reaction
  • Retrospective Studies
  • United States
  • Vaginal Smears
  • Vaginitis / microbiology*


  • DNA, Fungal