Mapping by admixture linkage disequilibrium: advances, limitations and guidelines

Nat Rev Genet. 2005 Aug;6(8):623-32. doi: 10.1038/nrg1657.


Mapping by admixture linkage disequilibrium (MALD) is a theoretically powerful, although unproven, approach to mapping genetic variants that are involved in human disease. MALD takes advantage of long-range haplotypes that are generated by gene flow among recently admixed ethnic groups, such as African-Americans and Latinos. Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations. It will also require 200-500 times fewer markers, providing a significant economic advantage. The MALD approach is now being applied, with results expected in the near future.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Chromosome Mapping*
  • Epidemiology* / ethics
  • Humans
  • Linkage Disequilibrium*
  • Practice Guidelines as Topic