Prognostic significance of CD83 positive, mature dendritic cells in the gallbladder carcinoma

Oncol Rep. 2005 Aug;14(2):353-6.

Abstract

Dendritic cells (DCs) are very potent antigen-presenting cells that play an essential role in the primary immune response to carcinoma. Tumor-infiltrating DCs have been found to be clinically significant in many human malignancies such as colon, stomach, lung, breast and hepatic carcinoma. However, clinical significance of activated and/or immature DCs in gallbladder carcinoma has not been reported yet. Thus, we immunohistochemically evaluated CD83+ DCs and CD1a+ DCs of cancerous and peritumoral area in 29 cases of resected gallbladder. In the results, CD83(+) DCs were significantly fewer in cancerous area than that in peritumoral area (1.55/hpf vs. 4.26/hpf, p=0.0047), but the numbers of CD1a(+) DCs did not differ (p=0.075). In addition, we defined a CD83 index as CD83(+) DCs/(CD83(+) DCs plus CD1a(+) DCs), and analyzed the relationship between CD83 index and clinicopathological factors. The group with a higher CD83 index (index >0.316) showed significantly better prognosis than the group with a lower CD83 index (index < or =0.316) in cancerous and peritumoral areas. In conclusion, we suggest the importance of tumor-infiltrating CD83(+) DCs as a useful prognostic factor for patients with gallbladder carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD
  • Antigens, CD1 / analysis
  • Cell Count
  • Dendritic Cells / chemistry*
  • Dendritic Cells / pathology
  • Gallbladder Neoplasms / metabolism
  • Gallbladder Neoplasms / mortality
  • Gallbladder Neoplasms / pathology*
  • Humans
  • Immunoglobulins / analysis*
  • Immunohistochemistry
  • Membrane Glycoproteins / analysis*
  • Prognosis
  • Survival Analysis
  • Survival Rate

Substances

  • Antigens, CD
  • Antigens, CD1
  • CD1a antigen
  • CD83 antigen
  • Immunoglobulins
  • Membrane Glycoproteins