Antibiotic-related renal failure and cystic fibrosis

J Paediatr Child Health. 2005 Jul;41(7):382-3. doi: 10.1111/j.1440-1754.2005.00640.x.


Recently published reports suggest that the combination of aminoglycosides with ceftazidime may increase the risk of renal disease in cystic fibrosis. We describe a case of unusually severe acute tubular necrosis occurring in an adolescent with cystic fibrosis receiving i.v. gentamicin plus ceftazidime and discuss the possible mechanisms.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Aminoglycosides / adverse effects
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects*
  • Bacterial Infections / complications
  • Bacterial Infections / drug therapy*
  • Cystic Fibrosis / complications*
  • Drug Combinations
  • Female
  • Humans
  • New South Wales
  • Renal Dialysis
  • Renal Insufficiency / chemically induced*
  • Renal Insufficiency / therapy


  • Aminoglycosides
  • Anti-Bacterial Agents
  • Drug Combinations